SAM-e, 400mg Double-Strength – 60 tablets
80.96€
Quantity discount
| Quantity | 2 | 3 | 4 | 5+ |
|---|---|---|---|---|
| Price | 77.72€ | 76.10€ | 73.67€ | 71.24€ |
50 in stock
Estimated delivery time 5-7 business daysDoctor’s Best – SAM-e
What is Doctor’s Best Doctor’s Best SAM-e?
Doctor’s Best SAM-e is proven to enhance mood and promote cognitive health. It is essential for the healthy metabolism of the major brain transmitters’ dopamine, serotonin and norepinephrine. In addition, SAM-e promotes joint comfort and mobility and supports liver health and detoxification. SAM-e effectiveness has been published in 18 controlled human trials published over 40 years. Doctor’s Best SAM-e uses pharmaceutical grade materials. SAM-e is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. SAM-e optimized for potency, stability, and to survive the stomach acid and reach the intestine (where it is absorbed). Effectiveness of SAM-e has been backed by at least 18 controlled human trials published over almost four decades.
How does it work?
S-Adenosyl Methionine (SAM-e) is produced by the body from ATP and the amino acid methionine which is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAM-e is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAM-e is also required for the biosynthesis of critical neurotransmitters and hormones.
Why should I take Doctor’s Best SAM-e?
SAM-e is a biological compound found in every living cell of the human body, vital to their function, stability and activity and involved in more than one hundred biochemical reactions and specific processes. SAM-e helps promote healthy mood. So if your body is not producing enough SAM-e, you might feel blue or have trouble sleeping. And according to the Center for Disease Control, an estimated 1 in 10 American adults say they are depressed. Supplementing with Doctor’s Best SAM-e can help and improve your quality of life.
| Best before | 2027-07-31 |
|---|---|
| Country of origin |
Ingredients
SAM-e – 400mg Double-Strength – 60 tablets
Ingredients:
S-Adenosyl Methionine (from SAM-e tosylate disulfate)
Other ingredients:
Microcrystalline cellulose, magnesium hydroxide, stearic acid, calcium chloride anhydrous, magnesium stearate, colloidal silica anhydrous, calcium oxide, magnesium silicate, natural food glaze, arginine base, glycerol, sodium alginate.
Recommended use:
Take 1 tablet twice daily between meals, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.
Warnings:
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people. Gluten Free, Vegan, Soy Free. Store in a cool dry place.
Nutrition Facts
Serving Size: 1 Tablet
Servings Per Container: 60
Amount
Per Serving
%RI*
S-Adenosyl Methionine (from SAM-e tosylate disulfate)
200 mg
*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
23 reviews for SAM-e, 400mg Double-Strength – 60 tablets
Only logged in customers who have purchased this product may leave a review.
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Ecosupplements customer (verified owner) –
trust Dr’s Best as a brand and am glad Ecosupplements stock them. I take SAMe to help me maintain a good mood and for my joints. I take other supplements, especially collagen powder and NOW UCII Undenatured Callgen type 2, which also help my joints. What I notice most about SAMe is that it relieves what can be a bad mood, especially in difficult and stressful times, and I feel good and able to handle difficult situations better. I take 400mg a day to get the result I want. It’s an ongoing expense – but worth it to me.
Ecosupplements customer (verified owner) –
I bought this for my brother’s depression. He was skeptical at first, but after 3 days he said he noticed a huge boost in energy and mood. I can’t take this brand unfortunately because the arginine base gives me cold sores, so I’m taking the Ecosupplementss Life Extension brand instead. I highly recommend this brand as it seems to be very powerful/effective for depression.
Ecosupplements customer (verified owner) –
SAM0e is a basic supplement for cystic fibrosis. This brand uses quality ingredients and the tablets are an easy to swallow size. It may have beneficial effects on mood, attention and depression and supports liver function. It is tasteless and tests show it is well absorbed. The package contains a foil wrapper for the tablets.
Ecosupplements customer (verified owner) –
don’t know what they put in this thing, but it works. I’m a person who can be easily irritated at times and this stuff keeps me cool, calm and collected. It makes me feel emotionally balanced. I don’t know why I didn’t discover this stuff sooner.
Lucy Annie (verified owner) –
I took this on an empty stomach and within an hour my seritonin level went up and I felt so happy & peaceful! I am so thankful to find this!
Ecosupplements customer (verified owner) –
This product is amazing. I suffered for years from chronic fatigue, brain fog, poor memory, sleep problems, muscle pain, joint pain, and low mood. SAM-e started changing that for me within days. I sleep better and I have regained energy. The arthritis I was starting to develop doesn’t bother me anymore and I’m focused and efficient at work. I also feel happy and motivated. I don’t know what I would do without it. Dr’s Best is just as effective as the more expensive brands I’ve tried and the price is great. Ecosupplements offers free and fast delivery. I have recommended this product to a dozen friends who have all reported similar results and are absolutely convinced of it. A life changer!
Ecosupplements customer (verified owner) –
Doctor’s Best manufactures SAM-e tablets that deliver the expected efficacy. Not all SAM-e are the same! Based on previous experience, I now avoid those containing ”methionine” only, as SAM-e is effective for anxiety with ”L-methionine”. My daughter went from 3-4 panic attacks a day to 3-4 a day. week on Celexa (an SSRI) to ZERO panic attacks with SAM-e, and her baseline anxiety also decreased, making her more able to enjoy life. Doctor’s Best SAM-e took care of the hives I had because it’s an antihistamine. Good product!
Ecosupplements customer (verified owner) –
High dosage of quality saM-e from a reputable brand. The tablets are enteric coated (important for SAMe absorption and each tablet is individually sealed for freshness (great packaging). I use this as a double claw remedy to support the liver and joints and works great for me. A (noticeable) better mood is a nice bonus too.
Ecosupplements Customer (verified owner) –
I really like this product its not always available but I find it really helpful
Paulo (verified owner) –
I bought this medicine for my parents and the benefits are huge.
Mutant Jean (verified owner) –
Docter’s Best Double Strength SAM-E 400 has given me a much calmer attitude. Both my niece and I have noticed the difference!
Ecosupplements customer (verified owner) –
actually ordered it as a mild antidepressant, although it’s a liver medicine, I’ve heard it helps a lot in improving mood. The size of the pills is huge. I haven’t taken it long enough to talk about effects but I’ll update it once I notice anything.
ZWoman (verified owner) –
The first SAM-e product I ordered caused stomach upset & bloating. (BTW- Ecosupplements was nice enough to refund my purchase for this initial product.) The issue was the same kind of bloating I experience with sugar-free candy or puddings, so I checked ingredients: Sure enough, both contain mannitol, a sugar alcohol that is the culprit. SO, I researched other products & Doctor’s Best SAM-e was the one brand I found that does NOT contain this additive. A CSR from that company was also kind enough to return my call to confirm that fact. I have been taking this product for nearly 2 weeks now with no side effects. Still within window of time to determine effectiveness for which it was prescribed, but am so glad it doesn’t have the stomach issues so many users describe. Give it a try!
Ecosupplements customer (verified owner) –
take SAMe because I have foie gras. Just a mild form of fatty liver disease. I take it with silibinin/sylibin. 400 mg in the morning on an empty stomach and 400 mg in the evening before going to bed. After two months, SAMe and silibinin were able to lower my transaminases. Gamma-GT as well as GPT and GOT were then back in the normal range. I also gave SAMe to my dog. He had been on corticosteroids for some time for a joint problem. GPT, GOT, gamma-GT and alkaline phosphatase were increased. After three weeks of 2 x 400 mg of SAMe, liver values had returned to normal.
Ecosupplements customer (verified owner) –
Doctors Best has become our favorite family brand! The product is a supplement for improving health, immunity, quality of life, well-being and mood. I bought it out of curiosity after reading “Vitamin” in the title of the search results. It has fulfilled some essential needs that I had until now: a boost of energy and an elimination of fatigue due to long flights and stress.
None (verified owner) –
I have bought this several times from your site. I love the convenience of the 60 tab packages and your price. The other plus is the speed of delivery. It is always here the 2nd day after ordering. Will continue to order this product from you. Thank you.
Healthy living (verified owner) –
I have been taking this supplement for several months. It was recommended by a friend when I was dealing with some painful family issues.I am still taking it now because I really noticed a difference in my mood and sense of contentment after the first few weeks.
Ecosupplements Customer (verified owner) –
Very helpful.
Mott1106 (verified owner) –
I have been buying this brand and this strength for over 10 years now. Have tried other brands but Dr’s Best through Ecosupplements is, hands down, the absolute best for us!
Ecosupplements Customer (verified owner) –
Excellent for health all of us need it
Ecosupplements Customer (verified owner) –
Dear,
Last Friday when my mood is really down, I took one pill and my mood get stable and went to work at the office.
Ecosupplements Customer (verified owner) –
I Have been taking this product for 4-5 years
No longer have arthritis stiffness or joint pain. Tried other brands that did not produce the same relief. doctors best high potency and dosage works the BEST!
sheplassie (verified owner) –
I wish I could say that my mood was really good, but I know it could be better. I do think it makes a bit of a difference which is good.