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FlexAnew contains Glucosamine, Chondroitin, Calcium and Nexrutine (Phellodendron Amurense), a natural COX-2 enzyme inhibitor. Glucosamine and Chondroitin are substances that are produced in our bodies naturally and help serve as building blocks for our connective tissues. Glucosamine and Chondroitin also help provide comfortable movement and flexibility by aiding in the generation of healthy cartilage and joint lubricating fluids. Patent-pending ingredient Nexrutine has been scientifically shown to inhibit the COX-2 enzyme.